Meta-Analysis of the association of FCER1B, FCER2, and ADAM33 gene polymorphisms with asthma

Asthma is a complex heterogeneous disease, the development of which determined by interaction many predisposition genes and environmental factors. Many epidemiological studies have shown that single nucleotide polymorphism (SNP) in FCER1B (rs1441586), FCER2 (28364072), ADAM33 (rs528557) are associated with risk asthma. However, results inconsistent inconclusive. The aim this study was to determine whether polymorphisms confer susceptibility To derive more precise estimation, meta-analysis performed. Meta-analysis conducted data from case-control association (20 9954 controls 8261 cases). Comprehensive Meta-Analysis software used for statistical analysis. A random-effects model calculate summary odds ratios (ORs). showed no between asthma rs1441586 variant under any genetic model. noticeable (rs28364072) overall pooled subjects observed dominant, recessive, allele contrast models. Moreover, statistically significant were obtained This illustrates may increase